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Reflexes and the reflex arc

In the knee-jerk reflex the sensory neuron talks straight to the motor neuron, with no brain in the loop.

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A cross-section of the spinal cord with the nerves of one reflex. Press Start, or leave Repeat on, and watch the steps light up in order. Switch between Knee jerk and Withdrawal in the list.

Fast answers that skip the cortex

A reflex is an automatic response to a stimulus. Simple somatic reflexes do not involve the higher centres of the brain that handle conscious, voluntary movement, which is why they are quick and why they look the same every time. Some reflexes run through the spinal cord and are called spinal reflexes; others run through the brain stem and cranial nerves and are called cranial reflexes. In the 1890s Charles Sherrington showed how muscle contractions are followed by relaxation, and how different reflexes work together as the spinal cord and brain turn incoming impulses into new ones for muscles and organs.

Five parts of a reflex arc

The path a reflex takes is the reflex arc, and it has five parts. A receptor detects the stimulus. A sensory neuron carries the signal into the spinal cord through the dorsal root; its cell body sits in the dorsal root ganglion just outside the cord. In the gray matter the signal is passed on, either directly or through one or more interneurons. A motor neuron, with its cell body in the anterior horn, sends the command out through the ventral root. Finally the effector, a muscle or a gland, responds. In the model these five steps light up one after another.

Receptor, sensory neuron, integration in the spinal cord, motor neuron, effector.

The knee jerk: a stretch reflex

When a doctor taps the patellar ligament just below the kneecap with a rubber hammer, the tap stretches the big muscle on the front of the thigh. Muscle spindles inside that muscle sense the stretch. Their sensory axons enter the spinal cord and connect directly with the motor neurons of the same muscle, which contracts and makes the lower leg kick forward. A branch of the sensory fibre also acts through an interneuron to inhibit the motor neurons of the opposing muscles at the back of the thigh, so they do not pull against the kick. In daily life the stretch reflex helps hold muscles at a steady length.

Pulling away: the withdrawal reflex

Touch a hot stove and pain receptors in the skin fire. In the dorsal horn of the spinal cord the sensory neuron excites an interneuron, which drives the motor neurons of the biceps, and the elbow bends to pull the hand away. At the same time another interneuron inhibits the motor neurons of the triceps. Without that opposing contraction the withdrawal is faster, which limits the damage. Step on a sharp stone and a similar arc lifts the foot: interneurons cancel the push-down movement of the calf muscles while the muscle at the front of the shin lifts the foot. A copy of the signal also climbs the spinal cord to the brain. That is how you come to feel the pain and remember the stove, but the reflex does not wait for it.

Reflexes in the head, and in babies

The corneal reflex protects the eye. When something touches the cornea, or in a related reflex when bright light hits it, you blink. This arc runs through cranial nerves and the brain stem, and doctors often check it with a gentle puff of air or a light touch with a cotton tip. Newborns have a set of reflexes of their own, which are thought to have helped survival before the modern age and fade as the baby grows. In the Babinski reflex, stroking the sole makes the big toe extend upward and the other toes fan out.

This lesson explains how reflexes work. It is not a way to check your own health.
BackgroundThe word synapse first appeared in print in 1897, in the seventh edition of Michael Foster's Textbook of Physiology. Foster's co-author for the volume on the nervous system was Charles Sherrington, who developed the idea of a junction between neurons; the word itself was suggested by a Cambridge classicist, Arthur Verrall. In 1906 Sherrington gathered his work on reflexes into a book, The Integrative Action of the Nervous System, and in 1932 he shared the Nobel Prize in Physiology or Medicine with Edgar Adrian for discoveries about the functions of neurons.
ReflexAutomatic response to a stimulus, without the higher brain centres.
Reflex arcReceptor, sensory neuron, integration, motor neuron, effector.
Muscle spindleReceptor inside a muscle that senses stretch.
InterneuronNeuron in the CNS that links other neurons.
Dorsal root ganglionCell bodies of sensory neurons, just outside the cord.
EffectorThe muscle or gland that carries out the response.
Corneal reflexBlink when the cornea is touched.
Babinski reflexNewborn reflex: stroking the sole spreads the toes.
  1. Put the parts of a reflex arc in order.
  2. In the knee jerk, what senses the stretch?
    • Muscle spindles in the thigh muscle
    • Pain receptors in the skin
    • The cerebellum
    • The kneecap bone
  3. What is special about the knee-jerk arc?
    • The sensory neuron acts directly on the motor neuron
    • It must pass through the cortex
    • It uses no motor neuron
    • It runs through the optic nerve
  4. In the withdrawal from a hot stove, which muscle is inhibited?
    • Triceps
    • Biceps
    • Quadriceps
    • Diaphragm
  5. Where are the cell bodies of the sensory neurons in a spinal reflex?
    • Dorsal root ganglion
    • Anterior horn
    • Cerebellum
    • Muscle
  6. Where are the cell bodies of the motor neurons?
    • Anterior (ventral) horn of the gray matter
    • Dorsal root ganglion
    • White matter
    • Skin
  7. Why are simple reflexes fast?
    • They skip the higher brain centres and use few synapses
    • They use thicker blood vessels
    • They are controlled by hormones
    • They happen only during sleep
  8. Which reflex is tested with a gentle puff of air to the eye?
    • Corneal reflex
    • Knee jerk
    • Babinski reflex
    • Withdrawal reflex
  9. Newborn reflexes such as the Babinski reflex...
    • Fade as the baby grows
    • Get stronger with age
    • Appear only in adults
    • Are learned from parents
  10. Made-up example: a sensory signal travels 0.9 m at 60 m/s. How many milliseconds does that take?
  11. Who developed the idea of the synapse, a word first printed in 1897, and later shared the 1932 Nobel Prize?
    • Charles Sherrington
    • Paul Broca
    • Camillo Golgi
    • Otto Loewi
Key points
  • A reflex is automatic and does not need the higher brain centres.
  • Reflex arc: receptor, sensory neuron, integration, motor neuron, effector.
  • Knee jerk: muscle spindle, sensory neuron straight to motor neuron; the opposing muscle is inhibited.
  • Withdrawal: pain receptor, interneuron, biceps contracts, triceps inhibited.
  • The signal to the brain arrives after the reflex has started.

This is educational material about how the body is built and works. It is not medical advice and is not for diagnosing or treating anyone.

Sources for this course (11)
  • OpenStax Anatomy and Physiology 2e , 12.1 Basic Structure and Function of the Nervous System, 12.2 Nervous Tissue, 12.4 The Action Potential, 12.5 Communication Between Neurons, 13.2 The Central Nervous System, 13.4 The Peripheral Nervous System, 14.1 Sensory Perception, 14.2 Central Processing, 14.3 Motor Responses, 15.1 Divisions of the Autonomic Nervous System (openstax.org/books/anatomy-and-physiology-2e)
  • NIH NINDS "Brain Basics: Know Your Brain" and "Brain Basics: Understanding Sleep" (ninds.nih.gov/health-information/public-education/brain-basics)
  • NIH MedlinePlus "Healthy Sleep" (medlineplus.gov/healthysleep.html)
  • NIH Research Matters "Scientists build largest maps to date of cells in human brain" (nih.gov, about 86 billion nerve cells)
  • Basic Neurochemistry, Brain Energy Metabolism (ncbi.nlm.nih.gov/books/NBK28124, about 20% of the body's oxygen) and Balasubramanian 2021 "Brain power" (PMC8364152, 2% of body weight)
  • nerve conduction speeds: ScienceDirect Topics "Nerve Conduction" (myelinated up to 120 m/s, unmyelinated 0.5 to 3 m/s) and Erlanger and Gasser fibre table in "Nerve Fiber" (C fibres 0.6 to 2 m/s)
  • history: NobelPrize.org 1906 (Golgi, Cajal) and 1932 (Sherrington)
  • Tansey 1997 "Sherrington and the synapse, 1897" (PubMed 9323432)
  • PMC4291908 (Loewi 1921, Nobel 1936 with Dale)
  • PMC3424716 (Hodgkin and Huxley 1952, Nobel 1963)
  • Britannica "Broca area" (1861) and PubMed 29452328 (Leborgne, "Tan")

Checked: 2026-10-17